Allopurinol - Chronic Gout Treatment: What You need to know About Allopurinol
Allopurinol (which goes by the brand names Aloprim and Zyloprim) is a drug that belongs to a class of drugs called xanthine oxidase inhibitors. Allopurinol is prescribed for the treatment of chronic gout and also is employed to prevent rather than treat gout attacks.
The medicine works by blocking uric acid production. Uric acid is a waste product usually present in the blood as a result of the breakdown of purines. Excessive amounts of uric acid can cause crystals to form in the joints, which can lead to gout.
When is Allopurinol Prescribed?
Allopurinol is prescribed to prevent chronic gout attacks, manage high uric acid levels caused by cancer medications, as well as handle kidney stones. There are also a number of off-label uses for which your doctor may prescribe allopurinol.
What is the Option of Allopurinol?
Allopurinol is available as a 100 mg. tablet. It is taken a few times daily, usually after a meal.
Are There Virtually Any Special Directions Regarding How to Take Allopurinol?
Patients are advised to follow the prescribing instructions exactly. It is common for the starting serving of allopurinol to become low and gradually increased. Noticeable benefit from taking allopurinol may take months. Actually, during the first few months of use, the treatment may actually increase the number of gout attacks. Eventually, allopurinol will prevent gout assaults. In the interim, colchicine may be prescribed as well. Do not stop taking allopurinol even if you're feeling well.
Are There Patients Who Should Not Take Allopurinol?
Patients who are known to be allergic to allopurinol obviously should not take the medication. Patients taking any of the following medications should inform their particular doctor simply because they may require a dose adjustment:
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AmoxicillinAmpicillinCoumadinCytoxanPurinetholDiabineseDiureticsImmunosuppressantsOther gout medicationsWhat common side effects can occur along with allopurinol?
- Allopurinol can cause upset stomach, looseness of the bowels, and drowsiness.
- Rash is one of the more common side effects and can occur despite months or years of treatment.
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Are There More Severe Side Effects Related to Allopurinol?
Uncommon side effects that are worse if they occur include:
Hypersensitivy reactionsItchingBlood inside pee or pain when urinatingEye irritationSwelling around mouth or even lipsSigns of infectionLoss of urge for food or unexpected weight lossWhat special warnings and precautions are associated with allopurinol?
- Patients are advised to drink 8 glasses of water daily (unless a doctor instructs otherwise).
- Alcoholic drinks may decrease the effectiveness of allopurinol.
- Drinks or supplements containing ascorbic acid may be problematic in large quantities.
- Extreme vitamin C and allopurinol can combine to make urine acidic as well as cause kidney stones.
- Patients with kidney problems may need dose adjustment with regard to allopurinol.
Are There Special Instructions for Expecting or Even Nursing Women?
You are with child, breastfeeding, or planning on becoming pregnant, discuss allopurinol with your doctor. Few reports of allopurinol use during pregnancy exist. Although no adverse fetal outcomes associated with allopurinol have been noted in humans, allopurinol should only be used after weighing benefit to the patient vs. risk to the fetus.
How is It Determined that Allopurinol Will be an Effective Treatment?
Certain laboratory tests are periodically bought which help in order to determine if the drug is working effectively.
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Chris Randon is a nutritionist specialized in human health, and is based in Los angeles, Carlifornia.